Journal article
Low-Fouling Fluoropolymers for Bioconjugation and In Vivo Tracking
C Fu, B Demir, S Alcantara, V Kumar, F Han, HG Kelly, X Tan, Y Yu, W Xu, J Zhao, C Zhang, H Peng, C Boyer, TM Woodruff, SJ Kent, DJ Searles, AK Whittaker
Angewandte Chemie International Edition | WILEY-V C H VERLAG GMBH | Published : 2020
Abstract
The conjugation of hydrophilic low-fouling polymers to therapeutic molecules and particles is an effective approach to improving their aqueous stability, solubility, and pharmacokinetics. Recent concerns over the immunogenicity of poly(ethylene glycol) has highlighted the importance of identifying alternative low fouling polymers. Now, a new class of synthetic water-soluble homo-fluoropolymers are reported with a sulfoxide side-chain structure. The incorporation of fluorine enables direct imaging of the homopolymer by 19F MRI, negating the need for additional synthetic steps to attach an imaging moiety. These self-reporting fluoropolymers show outstanding imaging sensitivity and remarkable h..
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Funding Acknowledgements
A.W. acknowledges the financial support from Australian Research Council (CE140100036, DP0987407, DFP110104299, DFP180101221, LE0775684, LE0668517, and LE0882357) and the National Health and Medical Research Council (APFP1021759). C.F. acknowledges the University of Queensland for a UQ Development Fellowship (UQFEL1831361). T.M.W. acknowledges support from the National Health and Medical Research Council (APP1118881 and APP1105420). B.D. and D.J.S. acknowledge support from the Queensland Cyber Infrastructure Foundation (QCIF) and the University of Queensland Research Computing Centre. The Australian National Fabrication Facility, Queensland Node, is also acknowledged for access to some items of equipment.